H2N2V1, Main, Exploration, bibRecord, 001A19

Phylogenetically important regions of the Influenza A H1 hemagglutinin protein

Identifieur interne : 001A19 ( Main/Exploration ); précédent : 001A18; suivant : 001A20

Phylogenetically important regions of the Influenza A H1 hemagglutinin protein

Auteurs : Thomas G. Fanning [États-Unis] ; Jeffery K. Taubenberger [États-Unis]

Source :

Virus Research [ 0168-1702 ] ; 1999.

RBID : ISTEX:2ED9FACE149B55256B31D05536FD7223693E5FFC

English descriptors

KwdEn :
- Evolution, Hemagglutinin protein, Influenza A virus.
Teeft :
- Acid positions, Amino, Amino acid positions, Amino acids, Antigenic, Antigenic site, Antigenic sites, Avian, Bootstrap, Bootstrap value, Caton, Clade, Consistency index, Globular, Globular head, Hemagglutinin, Hemagglutinin protein, Hemagglutinin trimer, Immune, Parsimonious trees, Parsimony, Parsimony trees, Phylogenetic, Phylogenetic information, Phylogenetically, Random trees, Receptor, Receptor binding, Receptor binding site, Subtypes, Swine, Swine viruses, Taubenberger, Taubenberger virus research, Trimer, Virus hemagglutinin.

Abstract

Abstract: A parsimony approach was used to construct phylogenetic trees of the H1, H2 and H3 influenza hemagglutinin subtypes. The parsimony trees were then compared with randomly generated trees to identify regions of the proteins containing the most phylogenetic information, i.e. those regions making the parsimony trees shorter. We reasoned that any areas of the hemagglutinin protein that were phylogenetically ‘information-rich’ would be good candidates for sites involved in virus–host interactions and their identification might lead to a better understanding of the protein. Molecular modelling, based upon the crystal structure of the H3 hemagglutinin, demonstrated that most phylogenetically important regions of the H1 subtype were on the surface of the hemagglutinin trimer, primarily in the globular region. Many corresponded to known antigenic or receptor binding sites, while others appear to be novel and specific for H1.

Url:

https://api.istex.fr/ark:/67375/6H6-5GBB2SW2-H/fulltext.pdf

DOI: 10.1016/S0168-1702(99)00098-2

Affiliations:

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Le document en format XML

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<term>Bootstrap value</term>
<term>Caton</term>
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<term>Consistency index</term>
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<term>Globular head</term>
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<front><div type="abstract" xml:lang="en">Abstract: A parsimony approach was used to construct phylogenetic trees of the H1, H2 and H3 influenza hemagglutinin subtypes. The parsimony trees were then compared with randomly generated trees to identify regions of the proteins containing the most phylogenetic information, i.e. those regions making the parsimony trees shorter. We reasoned that any areas of the hemagglutinin protein that were phylogenetically ‘information-rich’ would be good candidates for sites involved in virus–host interactions and their identification might lead to a better understanding of the protein. Molecular modelling, based upon the crystal structure of the H3 hemagglutinin, demonstrated that most phylogenetically important regions of the H1 subtype were on the surface of the hemagglutinin trimer, primarily in the globular region. Many corresponded to known antigenic or receptor binding sites, while others appear to be novel and specific for H1.</div>
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Phylogenetically important regions of the Influenza A H1 hemagglutinin protein

Phylogenetically important regions of the Influenza A H1 hemagglutinin protein

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri